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Testosterone and Diabetes Link-The T4DM Study

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Testosterone and Diabetes Link-The T4DM Study

If you are male, over 50, and live in Australia in NSW, Vic, Qld, SA or WA, chances are you may have received and invitation to join the T4DM study.  The T4DM study is being run at 6 medical centres across Australia, and is a clinical trial exploring the link between testosterone and type 2 diabetes.  Specifically the study is investigating whether testosterone treatment, combined with a lifestyle program can prevent type 2 diabetes in men with pre-diabetes(2) and low testosterone.  The study is comprehensive, targeting a sample size of 1500 Australian men who do not have diabetes to join the study for around two years.

A link between diabetes and testosterone has been noted for some time. For example a study published in 2013 reported that low testosterone levels may help predict if a man will type 2 diabetes in the future.  In this study, a group of more than 300 obese and non-obese men note the following:

·         44 percent had both type 2 diabetes and low testosterone

·         Only 33 percent who had low testosterone but did not have diabetes.

·         25 percent of those with type 2 diabetes and low testosterone were not obese, concluding that low testosterone is linked to insulin resistance regardless of body weight.


What Treatment Will Study Participants Receive?

·         The T4DM participants will receive free access to Weight Watchers. This includes access to Weight Watchers meetings as well as the online tools, trackers and forums.

·         Participants also receive either testosterone or placebo treatment. Neither you nor your study doctor will know whether you are receiving testosterone or placebo.  The treatment will be given as an injection at enrolment, 6 weeks later and then every 12 weeks for 2 to 4 years.  


Why join the T4DM study?

If you join the T4Dm study you will receive:

·         check whether you have pre-diabetes

·         check whether you have low or normal testosterone levels

·         receive 2 years of treatment with either testosterone or placebo free of charge

·         receive 2 years access to Weight Watchers free of charge

·         receive free regular health checks and monitoring from the study nurses and doctors



All medical treatments have some risks to consider, although testosterone injection is a routinely prescribed medicine side effects may occur in some people, such as:

·         Acne or pain at the injection site

·         A cough for a short time following an injection

·         Sometimes experience a temporary reduction in sperm count. This effect is reversible but may take months to wear off completely.

·         The treatments in this study are not expected to have any detrimental effect on your sexual function.


Are You Eligible?

The study is seeking  men aged 50 -74 years who live in NSW, Victoria, Queensland, South Australia or Western Australia.  Prospective participants first need to complete our online questionnaire to check whether the study will suit you.

Contact details for those men interested in participating:


Phone: 1300 865 436.

For more information watch the video below.    


(2)          What is Prediabetes?

Before people develop type 2 diabetes, they almost always have "prediabetes" which means blood glucose levels are higher than normal but not yet high enough to be diagnosed as diabetes. Recent research has shown that long-term damage to the body, especially the heart and circulatory system, may occur in people with prediabetes.

Some studies estimate that 10-25% of people in Western Countries may have prediabetes.

However, the good news is that appropriate intervention at the prediabetes stage can prevent progression to diabetes.

T4DM study


Disclaimer: The content of this article and other articles on this website are for informational purposes only and do not constitute professional advice. Please seek advice from a professional in the relevant field, in relation to any specific matter. Refer to the website Terms and Conditions. 



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